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AssigneeUniversity of Kentucky Research Foundation
InventorsPeixuan Guo, Hui Li, Emil Khisamutdinov, Daniel Jasinski
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The present invention is directed towards an artificial RNA nanostructure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a pRNA three-way junction (3WJ) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an immune response in a subject, or a combination thereof.
An artificial RNA nanostructure, comprising multiple external RNA stands and an internal RNA strand, wherein the internal strand and the external strands assemble to form a polygon nanostructure, wherein a pRNA three-way junction (3WJ) motif comprises each vertex of the nanostructure;
Dependencies are inferred from the claim text.