Back to results
US 10,378,016 B2Granted
Composition and method for oligonucleotide delivery
AssigneeChildren's Medical Center Corporation
InventorsJudy Lieberman, Lee Adam Wheeler
Life of this patent
Estimating the term…
Abstract
The invention provides aptamer-gene modulator conjugates, where the aptamer and the gene modulator are linked together. The invention further provides a method for cell-specific delivery of gene modulators to hard to transfect cells such as CD4+ cell.
Claims5
A conjugate comprising an aptamer and a gene modulator linked to each other by a linker, and wherein the aptamer is a CD4 aptamer, wherein the conjugate comprises nucleotide sequences selected from:
- (i) SEQ ID NOs:
- 58 and 68;
- (ii) SEQ ID NOs:
- 58 and 70;
- (iii) SEQ ID NOs:
- 59, 62, and 71;
- and (iv) SEQ ID NOs:
- 61 and 67.
5 more elements
Dependencies are inferred from the claim text.