Targeting hepatitis B virus (HBV) host factors
AssigneeUniversity of Massachusetts
InventorsAbraham L. Brass, Miles C. Smith
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Abstract
Described herein are methods of identifying host factors that modulate Hepatitis B virus (HBV) replication in mammalian, e.g., human cells, as well as factors identified by those methods, and methods of treating HBV infections by targeting those factors. Zinc finger, CCHC domain containing 14 (ZCCHC14) is an exemplary host factor.
Claims12
A composition comprising inhibitory nucleic acids targeting zinc finger, CCHC domain containing 14 (ZCCHC14) mRNA and inhibitory nucleic acids targeting Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Eta Isoform (YWHAH) mRNA, wherein the inhibitory nucleic acids comprise one or more modified bonds or nucleotides.
Dependencies are inferred from the claim text.