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US 10,378,014 B2Granted
Compositions and methods for the treatment of influenza infection
AssigneeLakewood Amedex, Inc.
InventorsRoderic M.K. Dale, Lun-Quan Sun
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Abstract
The invention provides compositions of oligonucleotides targeted at influenza genes and at host animal genes involved in response to influenza infection. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions of the invention for the treatment and prevention of influenza.
Claims21
A composition for treating an animal suffering from an influenza infection, the composition comprising:
- at least one modified antisense oligonucleotide containing about 12 to about 26 contiguous ribose groups linked by achiral 5′ to 3′ internucleoside phosphodiester linkages, wherein
- at least one ribose group of said at least one modified antisense oligonucleotide has a modified 2′ substituent, wherein said 2′ substituent is selected from the group consisting of methoxy, propoxy, methoxy-ethoxy, fluorine, chlorine, bromine, and iodine;
- the 3′ end of said at least one modified antisense oligonucleotide is end-blocked with an alkyl or an alcohol group;
- said at least one modified antisense oligonucleotide is complementary to a region of an influenza virus gene that encodes a NS1 protein;
- and
- wherein said antisense oligonucleotide is capable of inhibiting gene expression by blocking translation of mRNA;
- and
- an excipient.
5 more elements
Dependencies are inferred from the claim text.