Viral resistant cells and uses thereof
AssigneeSigma-Aldrich Co.
InventorsNan Lin, Joaquina Mascarenhas, Audrey Chang, David Onions, Henry George, Kevin Kayser
Life of this patent
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Abstract
The present invention provides mammalian cell lines that have been genetically engineered causing such cell lines to be resistant to viral entry and/or propagation, and provides methods of using said cell lines to reduce or prevent viral contamination of biologic production systems.
Claims11
A genetically modified mammalian cell line which is resistant to infection by minute virus of mouse (MVM), as compared to an unmodified parental cell line, wherein the genetically modified mammalian cell line, comprises a modified chromosomal sequence comprising an inactivated chromosomal sequence encoding St3 beta-galactoside alpha-2,3-sialyltransferase 4 (St3Gal4).
Dependencies are inferred from the claim text.