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US 10,377,899 B2Granted
Methods and materials for the production of monomers for nylon-4/polyester production
AssigneeInvista North America S.A R.L.
InventorsAlex Van Eck Conradie, Adriana Leonora Botes
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Abstract
This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.
Claims2
A recombinant host microorganism comprising:
- exogenous nucleic acids encoding (I) a glutamate decarboxylase (EC 4.1.1.15), and (II) an alcohol dehydrogenase selected from the group consisting of a 4-hydroxybutyrate dehydrogenase and a 5-hydroxyvalerate dehydrogenase, and (III) a first ω-transaminase (EC 2.6.1.29);
- or
- exogenous nucleic acids encoding (A) a 2-oxoglutarate decarboxylase (EC 4.1.1.71), and (B) an alcohol dehydrogenase selected from the group consisting of a 4-hydroxybutyrate dehydrogenase and a 5-hydroxyvalerate dehydrogenase,
- wherein the recombinant host produces 4-hydroxybutyrate.
1 more element
Dependencies are inferred from the claim text.