Back to results
US 10,377,826 B2Granted
Antigen binding constructs to CD8
AssigneeImaginab, Inc.
InventorsDavid T. Ho, Tove Olafsen, Giti Agahi, Christian P. Behrenbruch
Life of this patent
Estimating the term…
Abstract
Antigen binding constructs that bind to CD8, for example antibodies, including antibody fragments (such as scFv, minibodies, and cys-diabodies) that bind to CD8, are described herein. Methods of use are described herein.
Claims20
A antigen binding construct that comprises:
- a variable heavy (VH) domain comprising:
- a HCDR1 of a HCDR1 of SEQ ID NO:
- 3 or 6;
- a HCDR2 of HCDR2 of SEQ ID NO:
- 3 or 6;
- a HCDR3 of HCDR3 of SEQ ID NO:
- 3 or 6;
- a HFR3 of a HFR3 of SEQ ID NO:
- 48;
- and
- a variable light (VL) domain comprising:
- a LCDR1 of LCDR1 of SEQ ID NO:
- 9;
- a LCDR2 of LCDR2 of SEQ ID NO:
- 9;
- and
- a LCDR3 of LCDR3 of SEQ ID NO:
- 9.
15 more elements
A cys-diabody that binds to CD8, the cys-diabody comprising a polypeptide that comprises:
- a single-chain variable fragment (scFv) comprising a variable heavy (VH) domain linked to a variable light (VL) domain;
- and
- the VH domain comprising:
- a HCDR1 of a HCDR1 of SEQ ID NO:
- 3 or 6;
- a HCDR2 of a HCDR2 of SEQ ID NO:
- 3 or 6;
- a HCDR3 of a HCDR3 of SEQ ID NO:
- 3 or 6;
- and
- a HFR3 of a HFR3 of SEQ ID NO:
- 48;
- and
- the VL domain comprising:
- a LCDR1 of LCDR1 of SEQ ID NO:
- 9;
- a LCDR2 of a LCDR2 of SEQ ID NO:
- 9;
- and
- a LCDR3 of a LCDR3 of SEQ ID NO:
- 9.
18 more elements
A minibody that binds to CD8, the minibody comprising a polypeptide that comprises from N-terminus to C-terminus:
- a single-chain variable fragment (scFv) that binds to CD8, the scFv comprising a variable heavy (VH) domain linked to a variable light (VL) domain,
- the VH domain comprising:
- a HCDR1 of SEQ ID NO:
- 48;
- a HCDR2 of SEQ ID NO:
- 48;
- a HCDR3 of SEQ ID NO:
- 48;
- a HFR3 of a HFR3 of SEQ ID NO:
- 48;
- and
- the VL domain comprising:
- a LCDR1 of SEQ ID NO:
- 42;
- a LCDR2 of SEQ ID NO:
- 42;
- and
- a LCDR3 of SEQ ID NO:
- 42;
- a hinge-extension domain comprising a IgG1 hinge region;
- and
- a IgG CH3 sequence.
19 more elements
Dependencies are inferred from the claim text.