Compositions and methods for the treatment of immune related diseases
AssigneeGenentech, Inc.
InventorsHilary Clark, Dan Eaton, Lino Gonzalez, Jr., Jane Grogan, Jason A. Hackney, Kristin Bowles, Xin Yu
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Abstract
The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.
Claims12
An anti-TIGIT antibody, or antigen-binding fragment thereof, comprising a light chain comprising an HVR-L1 comprising SEQ ID NO:
- 23, an HVR-L2 comprising SEQ ID NO:
- 24, and an HVR-L3 comprising SEQ ID NO:
- 25, and a heavy chain comprising an HVR-H1 comprising SEQ ID NO:
- 26, an HVR-H2 comprising SEQ ID NO:
- 27, and an HVR-H3 comprising SEQ ID NO:
- 28.
An anti-TIGIT antibody, or antigen-binding fragment thereof, comprising a light chain comprising the amino acid sequence set forth in SEQ ID NO:
- 21 and a heavy chain comprising the amino acid sequence set forth in SEQ ID NO:
- 22.
An anti-TIGIT antibody, or antigen-binding fragment thereof, comprising a light chain comprising an HVR-L1 comprising SEQ ID NO:
- 31, an HVR-L2 comprising SEQ ID NO:
- 32, and an HVR-L3 comprising SEQ ID NO:
- 33, and a heavy chain comprising an HVR-H1 comprising SEQ ID NO:
- 34, an HVR-H2 comprising SEQ ID NO:
- 35, and an HVR-H3 comprising SEQ ID NO:
- 36.
An anti-TIGIT antibody, or antigen-binding fragment thereof, comprising a light chain comprising the amino acid sequence set forth in SEQ ID NO:
- 29 and a heavy chain comprising the amino acid sequence set forth in SEQ ID NO:
- 30.
Dependencies are inferred from the claim text.