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US 10,377,819 B2Granted
Methods for treating osteogenesis imperfecta
AssigneesGenzyme Corporation, Baylor College of Medicine
InventorsBrendan Lee, Kuber T. Sampath
Life of this patent
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Abstract
The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a binding agent that binds to transforming growth factor beta (TGFβ).
Claims8
A method for treating osteogenesis imperfecta (OI) in a human subject in need thereof, comprising
- administering to the subject a therapeutically effective amount of an antibody that binds to transforming growth factor beta (TGFβ) in combination with a bisphosphonate,
- wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 10, and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 11.
1 more element
A method for treating osteogenesis imperfecta (OI) in a human subject in need thereof, comprising
- administering to the subject a therapeutically effective amount of an antibody that binds to transforming growth factor beta (TGFβ) in combination with teriparatide,
- wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 10, and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 11.
1 more element
Dependencies are inferred from the claim text.