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US 10,377,815 B2Granted
Bispecific antibodies and fusion proteins that bind to EBOV and NPC1
AssigneeAlbert Einstein College of Medicine
InventorsKartik Chandran, Anna Z. Wec, Elisabeth K. Nyakatura, Jonathan R. Lai
Life of this patent
Estimating the term…
Abstract
Disclosed are bispecific antibodies and bispecific fusion constructs that bind to Niemann-Pick CI (NPC1) receptor for treating or preventing filovirus infections, pharmaceutical compositions comprising the bispecific antibodies, and therapeutic methods using the bispecific antibodies.
Claims9
A monoclonal antibody or fragment thereof that binds to Niemann-Pick C1 (NPC1) receptor, the antibody or fragment thereof comprising
- a variable region of a light chain that comprises the amino acid sequence set forth in SEQ ID NO:3 and a variable region of a heavy chain that comprises the amino acid sequence set forth in SEQ ID NO:4;
- or
- a variable region of a light chain that comprises the amino acid sequence set forth in SEQ ID NO:5 and a variable region of a heavy chain that comprises the amino acid sequence set forth in SEQ ID NO:6;
- or
- a variable region of a light chain that comprises the amino acid sequence set forth in SEQ ID NO:7 and a variable region of a heavy chain that comprises the amino acid sequence set forth in SEQ ID NO:8.
2 more elements
Dependencies are inferred from the claim text.