Vinblastine derivatives, preparation method therefor and application thereof

A method for treating a disease in a subject comprising:

• administering to a subject a composition comprising a vinca alkaloid derivative, wherein the vinca alkaloid derivative is selected from a hydrazinolyzed vinca alkaloid and physiologically acceptable salts thereof, and a vinca alkaloid dipeptide derivative and physiologically acceptable salts thereof;
• wherein the hydrazinolyzed vinca alkaloid is JJ-CCXJ or JJ-CCFN shown as follows:
• and wherein the vinca alkaloid dipeptide derivative is selected from the group consisting of BX-CCXJ, BX-CCJ, BX-CCRB and BX-CCFN shown as follows
• wherein, -PG-Z represents a benzyloxycarbonylglycylprolyl group having the structure as follows
• wherein the disease is a cancer selected from the group consisting of Hodgkin's lymphoma, non-Hodgkin's lymphoma, acute lymphoblastic leukemia, testicular cancer, non-small cell lung cancer, stomach cancer, nasopharyngeal cancer, breast cancer, intestinal cancer, liver cancer, leukemia, prostate cancer, cervical cancer, melanoma, ovarian cancer, neuroblastoma, nephroblastoma, rheumatoid arthritis, and diabetic retinopathy.