Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• X1 is C;
• X2 is
• R1 is —OH;
• R2 is (C1-C6) alkyl, (C6-C14) aryl, (C3-C8) cycloalkyl, or heterocycloalkyl, wherein the alkyl, aryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R8;
• R4 is (C1-C6) alkyl or (C6-C14) aryl, wherein the aryl is optionally substituted with one or more R12;
• R5 and R5′ are H;
• R7 is H;
• each R8 is independently (C1-C6) alkyl, halogen, —(C0-C4)-alkylene-aryl, —(C0-C4)-alkylene-heteroaryl, —(C0-C4)-alkylene-O-heteroaryl, —C(O)R21, wherein the alkyl, alkylene, aryl, and heteroaryl are optionally substituted with one or more R9;
• each R9 is independently (C1-C6) alkyl, halogen, or —NR23S(O)qR24;
• each R12 is independently (C6-C14) aryl, —O—(C3-C8)cycloalkyl, and halogen, wherein in the aryl and cycloalkyl are optionally substituted with one or more R13;
• each R13 is halogen;
• each R21 is (C2-C6) alkenyl;
• each R23 and R24 is independently H or (C2-C6) alkenyl;
• m is 0;
• n is 1;
• and
• q is 2.