Pyrrolo and pyrazolopyrimidines as ubiquitin-specific protease 7 inhibitors

A compound of Formula (Ig):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R2 is (C1-C8) alkyl, aryl, (C3-C8) cycloalkyl, or heterocyclyl, wherein the alkyl, aryl, cycloalkyl, and heterocyclyl are optionally substituted with one or more R8;
• R4 is (C1-C6) alkyl or —(C0-C3) alkylene-aryl, wherein the aryl is optionally substituted with one or more R12;
• each R8 is independently at each occurrence selected from (C1-C6) alkyl, —(C0-C4)-alkylene-aryl, —(C0-C4)-alkylene-heteroaryl, (C0-C4)-alkylene-O-heteroaryl, halogen, and —C(O)R10, wherein the alkyl, alkylene, aryl, and heteroaryl are optionally substituted with one or more R9;
• each R9 is independently at each occurrence selected from (C1-C6) alkyl, halogen, and —NR10S(O)qR11;
• each R10 and R11 is independently at each occurrence selected from H and (C2-C6) alkenyl;
• each R12 is independently at each occurrence selected from aryl, —O—(C3-C8)cycloalkyl, and halogen, wherein the aryl and cycloalkyl are optionally substituted with one or more R13;
• each R13 is independently at each occurrence selected from halogen;
• and
• each q is 2.