2-arylamino pyridine, pyrimidine or triazine derivatives, preparation method and use thereof

A compound represented by formula (I), or a pharmaceutically acceptable salt or a solvate thereof:

• wherein
• X is CH, Y is CH, Z is C—Ra, R1 is methoxy;
• or X is nitrogen, Y is CH, Z is C—Rb, R1 is methoxy or difluoromethoxy;
• or X is nitrogen, Y is nitrogen, Z is C—Rc, R1 is methoxy or difluoromethoxy;
• or X is nitrogen, Y is nitrogen, Z is C—Rd, R1 is difluoromethoxy;
• Ra is 3-methyl-1H-indazol-1-yl, 1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl, 1-methyl-1H-thieno[3,2-c]pyrazol-3-yl, 1-methyl-1H-pyrazolo[4,3-b]pyridin-3-yl, pyrazolo[1,5-a]pyrimidin-3-yl, or imidazo[1,2-a]pyridin-3-yl;
• Rb is benzo[d]isoxazol-3-yl, 1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl, 2,4-dimethyl-4H-thieno[3,2-b]pyrrol-6-yl, 2,5,6-trimethyl-6H-thieno[2,3-b]pyrrol-4-yl, or 1-methyl-1H-thieno[3,2-c]pyrazol-3-yl;
• Rc is 1H-benzo[d]imidazol-1-yl, 1H-indol-7-yl or 1-methyl-1H-indol-7-yl;
• Rd is 1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl;
• and
• R2 is (2-(dimethylamino)ethyl)(methyl)amino, 4-methylpiperazin-1-yl, 3-(dimethylamino)azetidin-1-yl, 4-(dimethylamino)piperidin-1-yl, (S)-2-((dimethylamino)methyl)pyrrolidin-1-yl, or 5-methyl-2,5-diazaspiro[3.4]oct-2-yl;
• provided that the compound is not