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US 10,377,745 B2Granted
Heterocyclic compounds as NaV channel inhibitors and uses thereof
AssigneeMerck Patent GmbH
InventorsBrian A. Sherer, Nadia Brugger
Life of this patent
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Abstract
The present invention relates to heterocyclic compounds, and pharmaceutically acceptable compositions thereof, useful as Nav1.6 inhibitors.
Claims10
A compound of formula I,
- or a pharmaceutically acceptable salt thereof, wherein:
- Z1 is C(R)(R);
- Z2 is C(R)(R);
- X is —O— or —NRC(O)—;
- or X is absent;
- A is selected from the following groups:
- R1 is hydrogen;
- each of R2, R3, R4, and R5, is independently H or C1-6 aliphatic;
- Y is —CH2—;
- Ring B is phenyl;
- each R6 is independently —OR;
- m is 0, 1, 2, or 3;
- n is 0, 1, 2, or 3;
- q is 1, 2, or 3;
- r is 1;
- and
- each R is independently hydrogen or unsubstituted C1-6 aliphatic.
14 more elements
Dependencies are inferred from the claim text.