AMPK-activating heterocyclic compounds and methods for using the same

A compound having the structural formula:

• or a pharmaceutically acceptable salt or N-oxide thereof, wherein
• one of X1 and X2 is N, and the others are CH or C substituted by one of the w R3;
• Y is N or CH;
• R1 is H;
• G is —CH2—, —C(O)— or S(O)2—;
• R17 is phenyl substituted with 0, 1 or 2 substituents each independently selected from methyl, ethyl, n-propyl, isopropyl, trifluoromethyl, pentafluoroethyl, acetyl, —NH2, —OH, methoxy, ethoxy, trifluoromethoxy, —SO2Me, -halogen, —NO2, N3, —SF5, and —CN;
• w is 0, 1 or 2;
• each R3 is independently selected from methyl, ethyl, n-propyl, isopropyl, trifluoromethyl, pentafluoroethyl, acetyl, —NH2, —OH, methoxy, ethoxy, trifluoromethoxy, —SO2Me, -halogen, —NO2 and —CN;
• Q is a single bond, —CH2—, —O—, —C(O)— or —S(O)2—;
• the ring system denoted by “A” is phenyl;
• each R5 is independently selected from methyl, trifluoromethyl, acetyl, methoxy, trifluoromethoxy, -halogen, —NO2, N3, —SF5, and —CN;
• and
• y is 0, 1 or 2.