US 10,377,733 B1Granted

Antimicrobials from an epigenetics based fungal metabolite screening program

AssigneesUniversity of South Florida, King Abdulaziz University

InventorsDanielle H. Demers, Bill J. Baker, Ala Azhari, Renee M. Fleeman, Dennis E. Kyle, Lindsey Neil Shaw

Life of this patent

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Abstract

Novel antimicrobial compounds against drug targets such as Eskape pathogens, Leishmania donovani, Mycobacterium tuberculosis, Clostridium difficile, Naegleria fowleri, and cancer are presented herein.

Claims3

Dependent claims

A method of inhibiting microbial activity in at least one cell comprising:

contacting the at least one cell with an effective amount of a Citreohybriddione compound, wherein the Citreohybriddione compound has the following formula:

Dependencies are inferred from the claim text.

Facts

Application: 16/023,602Filed 29 Jun 2018 · division
Priority: 27 Jul 2015
Granted: 13 Aug 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification17 codes

C07D 311/58
Benzo[b]pyrans, not hydrogenated in the carbocyclic ring: other than with oxygen or sulphur atoms in position 2 or 4
A61P 31/00
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C07C 49/757
Unsaturated compounds containing a keto groups being part of a ring: containing —CHO groups
C07C 65/19
Containing hydroxy or O-metal groups: having unsaturation outside the aromatic ring

Family

Application62/197,233Us provisional application · filed 27 Jul 2015
Application15/220,777Parent of this continuation-in-part · filed 27 Jul 2016
Application15/675,328Parent of this division · filed 11 Aug 2017
Application15/675,328Parent of this continuation-in-part
US 10,144,719 B1Related patent
US 2017/0050946 A1Published application
US 10,377,733 B1This patent

From the US filing history. Foreign family members aren’t listed.

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