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US 10,377,726 B2Granted
3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
AssigneeFORMA Therapeutics, Inc.
InventorsXiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Jr., David S. Millan, Matthew W. Martin
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Abstract
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
Claims10
A compound:
- or a pharmaceutically acceptable salt thereof.
A composition, comprising a compound:
- or a pharmaceutically acceptable salt thereof.
A process for preparing a compound:
- or a pharmaceutically acceptable salt thereof,
- comprising a step of treating an ester:
- with hydroxylamine and a first base to form the compound:
Dependencies are inferred from the claim text.