Rosuvastatin calcium and process for producing intermediate thereof

A production method of a compound represented by the following formula (2):

• wherein R is a primary alkyl group having 1-8 carbon atoms or a secondary alkyl group having 3-6 carbon atoms, the method comprising:
• (i) reducing a compound represented by the following formula (1a):
• wherein R is as defined for R in said formula (2), comprising reacting the compound with an enzyme having an activity capable of stereoselectively reducing a carbonyl group, a microorganism or cell having an ability to produce the enzyme, a treated product of the microorganism or cell, and/or a culture solution containing the enzyme obtained by culturing the microorganism or cell;
• wherein said enzyme comprises a polypeptide selected from:
• (A) a carbonyl reductase (OCR1) polypeptide of SEQ ID NO:
• 2 from Ogataea minuta var. nonfermentans NBRC1473,
• (B) a polypeptide consisting of an amino acid sequence having a homology of 90% or more to the amino acid sequence shown in SEQ ID NO:
• 2, and having an activity to convert a compound represented by said formula (1a) to a compound represented by said formula (2), and
• (C) a polypeptide comprising an amino acid sequence which is the amino acid sequence shown in SEQ ID NO:
• 2, wherein 20 or less amino acids are substituted, deleted or added, and having an activity to convert a compound represented by said formula (1a) to a compound represented by said formula (2).