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US 10,377,719 B2Granted
Trypanosomes inhibitors
AssigneeHoffmann-La Roche Inc.
InventorsMaude Giroud, Wolfgang Haap, Bernd Kuhn, Rainer E. Martin
Life of this patent
Estimating the term…
Abstract
The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Claims28
A compound of formula (I)
- wherein
- A is —C(O)— or —CHCF3—;
- R1 is propyl, pyridinyl or R3;
- R2 is (A), (B), (C), (D), (E), (F) or (G);
- R3 is (H);
- R4 is hydrogen, alkyl or haloalkyl;
- R5 is alkyl, haloalkyl, cycloalkyl, phenyl, halophenyl or alkoxyphenyl;
- R6 is halophenyl;
- R7 is halophenyl;
- R8 is alkyl;
- R9 is alkyl, cycloalkyl, halocycloalkyl, phenyl, halophenyl, alkylsulphanylphenyl, pyridinyl, halopyridinyl, oxanyl, azaspiro[3.3]heptyl, alkoxycarbonylazaspiro[3.3]heptyl, oxetanyl, pyrrolidinyl, alkoxycarbonylpyrrolidinyl, azetidinyl or alkylcarbonylazetidinyl;
- R10 is phenyl;
- R11 is halophenyl;
- R12 is phenyl or halophenyl;
- R13 is hydrogen, halogen, haloalkyl, haloalkoxy, cycloalkylalkoxy, phenylalkoxy, alkoxyalkoxy or cyano;
- R14 is hydrogen, halogen or haloalkyl;
- and
- R15 is hydrogen, halogen, cyano or haloalkyl;
- or a pharmaceutically acceptable salt or ester thereof;
- provided that N-[(1S)-1-[(3-chlorophenyl)methyl]-2-[(1-cyanocyclopropyl)amino]-2-oxoethyl]-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide is excluded.
17 more elements
The compound (S)—N-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-1-(1-cyanocyclopropylamino)-1-oxopropan-2-yl)-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide.
Dependencies are inferred from the claim text.