Farnesoid X receptor agonists and uses thereof

A compound of Formula (IV), or a pharmaceutically acceptable salt or solvate thereof:

• wherein:
• R1 and R2 are each independently selected from H, D, F, C1-C4alkyl, and C1-C4fluoroalkyl;
• ring A is a monocyclic carbocycle;
• each RA is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, and substituted or unsubstituted C1-C6heteroalkyl;
• ring B is a bicyclic heterocycle;
• each RB is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —N(R10)2, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R102, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, and substituted or unsubstituted C1-C6heteroalkyl;
• R3 is selected from substituted or unsubstituted C1-C10alkyl, or substituted or unsubstituted C3-C10cycloalkyl, wherein if R3 is substituted then R3 is substituted with one or more R12 groups;
• each R12 is independently selected from D, halogen, —CN, —NO2, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —S(═O)2N(R10)2, —NR10S(═O)2R11, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —N(R10)2, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, unsubstituted or substituted C1-C10alkyl, unsubstituted or substituted C1-C10fluoroalkyl, unsubstituted or substituted C2-C10alkenyl, unsubstituted or substituted C2-C10alkynyl, unsubstituted or substituted C1-C10heteroalkyl, and unsubstituted or substituted C3-C10cycloalkyl;
• R4 is absent or -L3-Y;
• L3 is absent, —C(R5)(R6)—, —C(R5)(R6)—C(R7)(R8)—, —O—C(R7)(R8)—, or —C(R5)(R6)—O—;
• R5 and R7 are each independently selected from H, D, C1-C4alkyl and C3-C6cycloalkyl;
• or R5 and R7 are taken together with the intervening atoms to form a double bond;
• or R5 and R7 are taken together with the intervening atoms to form an epoxide or a substituted or unsubstituted C3-C6cycloalkyl;
• R6 and R8 are each independently selected from H, D, C1-C4alkyl or C3-C6cycloalkyl;
• Y is -CH2OR9, -C(═O)OR9,
• R9 is selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted heterocycle;
• L1 is absent;
• ring C is phenyl, bicyclic carbocycle, monocyclic 6-membered heteroaryl containing 1-3 N atoms, or bicyclic heterocycle;
• each RC is independently selected from H, D, halogen, —CN, —OH, —OR10, —S(═O)R11, —NO2, —N(R10)2, —S(═O)2R11, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10 C(═O)N(R10)2, —NR10C(═O)R11, —NR10(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted monocyclic heteroaryl;
• each R10 is independently selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, and substituted or unsubstituted C3-C6cycloalkyl;
• or two R10 on the same N atom are taken together with the N atom to which they are attached to form a N-containing heterocycle;
• each R11 is independently selected from substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl;
• m is 0, 1, or 2;
• n is 0, 1, or 2;
• and
• p is 0, 1, 2, 3, or 4;
• wherein any substituted group is substituted with one or more groups individually and independently selected from D, halogen, —CN, —NH2, —NH(CH3), —N(CH1)2 —OH, —CO2H, —CO2( C1-C4alkyl), —C(═O)NH2, —C(═O)NH(C1-C4alkyl), —C(═O)N(C1-C4alkyl)2, —S(═O)2NH2, —S(═O)2NH(C1-C4alkyl), —S(═O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(═O)C1-C4alkyl, and —S(═O)2C1-C4alkyl.