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US 10,377,716 B2Granted
Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection
AssigneeTrustees of Dartmouth College
InventorsF. Jon Kull, Ronald K. Taylor, Gordon W. Gribble, Evans O. Onyango, Anne R. Kelley
Life of this patent
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Abstract
Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
Claims12
A compound or a hydrate, isomer, or pharmaceutically acceptable salt thereof having the structure:
- wherein
- R1 is C2-C6 alkyl;
- R2 is hydrogen, alkenyl, or oxo;
- X is —CHCH—, —NH—, —C═N—, or —N═C—;
- when X is —CHCH—, R2 is hydrogen, alkenyl, or oxo;
- when X is —NH—, —C═N—, or —N═C—, R2 is hydrogen, or oxo;
- n is 1-6.
4 more elements
A compound selected from the group consisting of:
- and hydrates, isomers, or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.