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US 10,377,715 B2Granted
18-20 member bi-polycyclic compounds
AssigneesHaro Pharmaceuticals Inc., The Royal Institution for the Advancement of Learning/Mcgill University, Universite de Montreal
InventorsDavid Bettoun, Eduardo Martinez, James Gleason, Sylvie Mader, Shuo Xing
Life of this patent
Estimating the term…
Abstract
The invention relates to 18-20 member bi-polycyclic compounds, methods of making these compounds, and methods of using them in treating hyperproliferative disorders (e.g., cancer) and non-malignant tumors; promoting muscle formation; inhibiting muscle degeneration or the loss of muscle mass or muscle function; and myofibers ex vivo.
Claims13
A compound of Formula I:
- A-W—Z (I) or a pharmaceutically acceptable salt thereof, wherein A is
- W is a heterocyclylene, arylene, heteroarylene, alkenylenearylene, arylenealkenylene alkenyleneheteroarylene, or heteroarylenealkenylene;
- and Z is —C(O)NR1R2, wherein R1 and R2 are each independently hydrogen (H), hydroxyl (OH), C1-6 alkyl, hydroxyC1-6 alkyl, aminoC1-6 alkyl, or aminoaryl;
- with the proviso that the compound is not
1 more element
Dependencies are inferred from the claim text.