Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof

A compound, or a pharmaceutically acceptable salt thereof, having the structure of formula (III):

• wherein:
• R1 is —OH, —OR4, —NHOR5, —NHSO2R4, —NR4R5, or R4;
• or —C(═O)R1 is a carboxylic acid bioisostere having the structure
• Ring A is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• Ring B is substituted or unsubstituted 6-membered heteroaryl;
• L2 is absent or —O—(C1-C6alkylene);
• R2 is hydrogen, halogen, nitro, —CN, —OH, —OR4, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, or substituted or unsubstituted C3-C6cycloalkyl;
• R3 is substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, or substituted or unsubstituted aryl;
• Z is —OH, —OR4, halogen, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, or substituted or unsubstituted C3-C6cycloalkyl;
• R4 is substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C3-C6cycloalkyl substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is hydrogen, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, or substituted or unsubstituted aryl;
• or R4 and R5 taken together with the nitrogen to which they are attached to form a substituted or unsubstituted C2-C8heterocycloalkyl;
• n is 0, 1, 2, 3, 4;
• and
• p is 0 or 1.