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US 10,377,062 B2Granted
Microneedle arrays formed from polymer films
AssigneeTransderm, Inc.
InventorsRoger L. Kaspar, Tycho Speaker
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Abstract
The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
Claims14
A method of manufacturing a transdermal drug delivery device having a microneedle array, comprising:
- providing a substrate;
- applying a polymer solution to the substrate to form a base layer;
- disposing an exposed surface of the base layer with a textured surface having elevated points protruding therefrom such that the elevated points contact the exposed surface of the base layer;
- distancing the textured surface from the exposed surface of the base layer such that the elevated points draw out tube-like projections from the exposed surface of the base layer, wherein the textured surface is distanced from the exposed surface of the base layer at a rate of about 0.1 mm/s to about 100 mm/s;
- drying the base layer having the tube-like projections to form microneedles, wherein drying includes exposing the base layer to reduced pressure;
- and
- trimming the microneedles to a predetermined length and tip-bevel to form the transdermal drug delivery device.
4 more elements
Dependencies are inferred from the claim text.