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US 10,376,694 B2Granted
Method and apparatus for stimulating the vascular system
OwnerVirender K. Sharmainventor
Life of this patent
Estimating the term…
Abstract
The present invention provides methods of treating a gastrointestinal condition. In some embodiments, the method generally includes administering a chemical or electrical stimulus to an artery of the gastrointestinal vasculature of the subject, a vein of the gastrointestinal vasculature of the subject, a nerve supplying an artery of the gastrointestinal vasculature of the subject, and/or a nerve supplying a vein of the gastrointestinal vasculature of the subject, wherein the chemical or electrical stimulus is effective for treating a gastrointestinal condition.
Claims16
A method of treating a gastrointestinal condition in a subject, the method comprising:
- providing an apparatus comprising a first electrode and a second electrode operably connected to a stimulus generator;
- placing the first electrode in direct contact with a portion of a celiac artery or a portion of a branch of a celiac artery of the subject in order to electrically stimulate the celiac artery or the branch of a celiac artery of the subject;
- placing the second electrode in electrical communication with a target comprising an artery of the gastrointestinal vasculature of the subject or a nerve supplying an artery of the gastrointestinal vasculature of the subject;
- causing the stimulus generator to generate an electrical stimulus administered to the portion of the celiac artery or the portion of the branch of a celiac artery through the first electrode, wherein the electrical stimulus administered through the first electrode induces a contraction in the celiac artery or the branch of a celiac artery;
- and
- causing the stimulus generator to generate an electrical stimulus administered to the target through the second electrode, wherein the electrical stimulus is effective to alter a flow of blood into the subject's gastrointestinal tract.
3 more elements
A method of treating a gastrointestinal condition in a subject, the method comprising:
- providing an apparatus comprising a first electrode and a second electrode operably connected to a stimulus generator;
- placing the first electrode in direct contact with a portion of a celiac artery or a portion of a branch of a celiac artery of the subject in order to electrically stimulate the celiac artery or the branch of a celiac artery of the subject;
- placing the second electrode in electrical communication with a target comprising a vein of the gastrointestinal vasculature of the subject or a nerve supplying a vein of the gastrointestinal vasculature of the subject;
- causing the stimulus generator to generate an electrical stimulus administered to the portion of the celiac artery or the portion of the branch of a celiac artery through the first electrode, wherein the electrical stimulus administered through the first electrode induces a contraction in the celiac artery or the branch of a celiac artery;
- and
- causing the stimulus generator to generate an electrical stimulus administered to the target through the second electrode, wherein the electrical stimulus is effective to alter a flow of blood into the subject's gastrointestinal tract.
3 more elements
A method of treating a gastrointestinal condition in a subject, the method comprising:
- providing an apparatus comprising at least two electrodes operably connected to a stimulus generator;
- placing a first of the at least two electrodes in direct physical contact with a first target comprising a portion of a celiac artery or a portion of a branch of a celiac artery of the gastrointestinal vasculature of the subject;
- placing a second of the at least two electrodes in electrical communication with a second target comprising a superior mesenteric artery or a branch of a superior mesenteric artery of the gastrointestinal vasculature of the subject;
- and
- causing the stimulus generator to generate an electrical stimulus transmitted to the first and second target through the at least two electrodes, wherein the electrical stimulus is effective to induce a contraction in the celiac artery or the portion of the branch of a celiac artery and to change a flow of blood into the subject's gastrointestinal tract through the portion of a celiac artery or the portion of a branch of a celiac artery.
2 more elements
A method of treating a gastrointestinal condition in a subject, the method comprising:
- providing an apparatus comprising at least two electrodes operably connected to a stimulus generator;
- placing a first of the at least two electrodes in direct physical contact with a first target comprising a portion of a celiac artery or a portion of a branch of a celiac artery of the gastrointestinal vasculature of the subject;
- placing a second of the at least two electrodes in electrical communication with a second target comprising an artery of the gastrointestinal vasculature of the subject;
- and
- causing the stimulus generator to generate an electrical stimulus administered to the first and second target through the at least two electrodes, wherein the electrical stimulus is effective to induce a contraction in a tone of the celiac artery or the portion of the branch of a celiac artery and to change a flow of blood into the subject's gastrointestinal tract through the portion of a celiac artery or the portion of a branch of a celiac artery.
2 more elements
Dependencies are inferred from the claim text.