System for closed transfer of fluids and membrane arrangements for use thereof

A system for closed transfer of fluids comprising:

• a syringe adapter comprising;
• a housing having a first end and a second end, the first end configured to be secured to a first container;
• a cannula having a first end and a second end, the second end positioned within the housing;
• and a collet having a first end and a second end, at least a portion of the collet received within the housing, the collet comprising a body defining a passageway, a first membrane received by the passageway of the collet, and a locking member connected to the body of the collet, the first membrane comprising a body having a first end and a second end, at least a portion of the body of the first membrane engaging the body of the collet, the body of the first membrane defining a passageway extending from the first end of the first membrane body towards the second end of the first membrane body and terminating intermediate the first and second ends of the first membrane body, the collet movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted,
• wherein, during movement of the collet from the first position to the second position, the first membrane is axially fixed to the collet relative to the locking member and the first membrane slides relative to the cannula, and
• wherein, in the second position of the collet, the second end first membrane body is pierced by the cannula and the collet is rotatable relative to the housing about a longitudinal axis of the housing;
• and
• the mating connector comprising a second membrane and a collet interface surface configured to receive and engage the locking member of the collet.

A syringe adapter comprising:

• a housing having a first end and a second end, the first end configured to be secured to a first container;
• a cannula having a first end and a second end, the second end of the cannula positioned within the housing;
• and
• a collet having a first end and a second end, at least a portion of the collet received within the housing, the collet comprising a body defining a passageway, a membrane received by the passageway, and a locking member connected to the body of the collet,
• wherein the membrane comprises a body having a first end and a second end, the body of the membrane including a first head portion and a second head portion, the first and second head portions extending radially outward from the body of the membrane and engaging the collet, the first head portion of the membrane including a frusto-conical surface, the second head portion of the membrane including a convex surface,
• wherein the collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted,
• wherein, during movement of the collet from the first position to the second position, the membrane is axially fixed to the collet relative to the locking member and the membrane slides relative to the cannula, and
• wherein, in the second position of the collet, the second end of the body of the membrane is pierced by the cannula and the collet is rotatable relative to the housing about a longitudinal axis of the housing.