Multilayered bone graft and method of making same
AssigneeThe Royal Institution for the Advancement of Learning/Mcgill University
InventorsFrancois Barthelat, Michael Tanzer, Sacha Cavelier
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Abstract
A synthetic bone graft is described which is adapted to be received within a bone defect and which is structurally load-bearing. The bone graft comprises an entirely synthetic graft body corresponding in shape and size to the bone defect. The graft body is composed of a plurality of superimposed multilayered structures, each of the multilayered structures having a biopolymer layer joined to a biomineral layer to define an interface therebetween. The biomineral layer has a stiffness that is greater than that of the biopolymer layer, and the biopolymer layer has a toughness that is less than that of the biomineral layer.
Claims14
A synthetic bone graft adapted to be received within a bone defect, the bone graft comprising an entirely synthetic graft body corresponding in shape and size to the bone defect and being structurally load-bearing, the graft body being composed of a plurality of superimposed multilayered structures, each of said multilayered structures having a biopolymer layer joined to a biomineral layer to define an interface therebetween, wherein the biomineral layer has a stiffness that is at least five times greater than that of the biopolymer layer, and the biopolymer layer has a toughness that is at least four times less than that of the biomineral layer.
A synthetic bone graft material comprising a plurality of superimposed multilayered structures, each of said multilayered structures having a biopolymer layer joined to a biomineral layer to define an interface therebetween, the biomineral layer being formed of a material selected from the group consisting of calcium sulfates and calcium phosphates, and the biopolymer layer being formed of a material selected from the group consisting of collagen and gelatin, wherein the biomineral layer has a stiffness that is at least five times greater than that of the biopolymer layer, and the biopolymer layer has a toughness that is at least four times less than that of the biomineral layer.
Dependencies are inferred from the claim text.