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US 10,376,603 B2Granted
Engineered fluorinated biomaterials
AssigneeNew York University
InventorsJin Kim Montclare, Joseph A. Frezzo, Cynthia Xu, Youssef Zaim Wadghiri
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Abstract
Provided are protein polymers providing the dual functionality of delivery and imaging. The protein polymers comprise a coiled-coil domain of the cartilage oligomeric matrix protein and repeats of elastic like peptides. The coiled-coil domain allows delivery of molecules, the elastin-like peptide domain provides thermo-responsive functionality, and a plurality of leucine residues, which can be fluorinated, provide imaging functionality.
Claims22
A protein polymer comprising from N- to C-terminus:
- a coiled coil domain of cartilage oligomeric matrix protein (COMPcc) or a variant thereof selected from the group consisting of SEQ ID NOs:
- 3-14;
- a linker sequence up to 30 amino acids, wherein the linker sequence comprises RGD and AT repeats and the RGD is directly N-terminal to the first AT repeat;
- and
- an elastin-like peptide domain comprising the sequence [(VPGXG)2VPGXG(VPGXG)2]n (SEQ ID NO:30), wherein n can be from 2 to 24, and X is any amino acid other than proline,
- wherein one or more leucine residues in the protein polymer are fluorinated.
3 more elements
A protein polymer comprising from the N- to the C-terminus:
- an N-terminal sequence comprising a polyhistidine sequence;
- a linker sequence comprising RGD and AT repeats, wherein the RGD is directly N-terminal to the first AT repeat sequence;
- a coiled coil domain of cartilage oligomeric matrix protein (COMPcc) or a variant thereof selected from the group consisting of SEQ ID NOs:
- 3-14;
- a linker sequence up to 30 amino acids and comprising RGD and AT repeats, wherein the RGD is directly N-terminal to the first AT repeat;
- and
- an elastin-like peptide sequence comprising the sequence [(VPGXG)2VPGXG(VPGXG)2]n (SEQ ID NO:30), wherein n can be from 2 to 24, and X is any amino acid other than proline,
- wherein one or more leucine residues in the protein polymer are fluorinated.
5 more elements
Dependencies are inferred from the claim text.