Antimicrobial compositions comprising single domain antibodies and pseudomonas exotoxin
AssigneeThe Johns Hopkins University
InventorsRichard Markham, Eileen Geoghegan
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Abstract
The present invention provides heavy chain immunoglobulins of the VHH type or fragment thereof having affinity for a target antigen of interest, including glycoprotein D2 (gD2) of HSV-2 or antigen thereof, and for envelope proteins of HIV-1 or an antigen thereof linked to Pseudomonas exotoxin A or functional fragments thereof. Also included are multimeric forms of the immunoglobulins and their use in the prevention and/or treatment of HSV2 and/or HIV-1.
Claims12
A heavy chain immunoglobulin of the VHH type or fragment thereof, wherein the heavy chain immunoglobulin of the VHH type or fragment thereof comprises an amino acid sequence of at least 90% identity to SEQ ID NO:
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Dependencies are inferred from the claim text.