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US 10,376,592 B2Granted
Stapled acid-sensitive endosome disrupting alginates
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsAbhinav Acharya, Stephen R. Little
Life of this patent
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Abstract
An agent comprising: an algin crosslinked with acetal linkages; and at least one cation coupled to the crosslinked algin.
Claims30
An agent comprising:
- an algin crosslinked with acetal linkages, wherein the acetal linkages have a structure of —X1-A-X2— wherein X1 and X2 are each independently —NH— or —O—, and A includes an acetal group;
- and
- at least one cation coupled to the crosslinked algin;
- wherein A is:
- wherein R10 and R11 are each independently an alkanediyl, and R12 and R13 are each optionally substituted alkyl.
2 more elements
An agent having a structure comprising:
- wherein M is a cation;
- X1 and X2 are each independently —NH— or —O—, and wherein A is;
- wherein R10 and R11 are each independently an alkanediyl, and R12 and R13 are each optionally substituted alkyl;
- or
- wherein M is a cation;
- X1 and X2 are each independently —NH— or —O—, and A is:
- wherein R10 and R11 are each independently an alkanediyl, and R12 and R13 are each optionally substituted alkyl;
- or a combination of Formula IV and Formula V.
5 more elements
Dependencies are inferred from the claim text.