Formulations and carrier systems including farnesylthiosalicylic moieties
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsSong Li, Yixian Huang, Xiaolan Zhang, Xiang Gao
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Abstract
A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.
Claims19
A method of forming a formulation, comprising:
- forming a carrier agent by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic oligomer or at least one hydrophilic polymer, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic oligomer or at least one hydrophilic polymer via a linkage which is labile in vivo, and
- associating a biologically active compound with the carrier agent.
Dependencies are inferred from the claim text.