Method for the treatment of a solid tumour
AssigneeThe University of Sydney
InventorsBrian Stanley Hawkett, Trevor William Hambley, Nicole Sarah Bryce, Thi Thuy Binh Pham, Nirmesh Jain
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Abstract
The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumor in a localized manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumors.
Claims7
A method of treating a solid tumour in a subject, said method comprising co-administering to said subject an effective amount of a non-cytotoxic particulate material and a cellular toxin effective to penetrate said solid tumor and induce cytotoxicity, wherein:
- (i) said non-cytotoxic particulate material is administered in the form of a dispersion in a liquid carrier, the non-cytotoxic particulate material being maintained in the dispersed state by a steric stabiliser;
- (ii) wherein said steric stabiliser comprises an anchoring portion and a steric stabilising polymeric segment;
- (iii) wherein the anchoring portion anchors the steric stabiliser to the non-cytotoxic particulate material, is different from the remainder of the steric stabiliser and has an affinity towards the surface of the particulate material and secures the steric stabiliser to the non-cytotoxic particulate material;
- (iv) wherein the cellular toxin is not attached to the non-cytotoxic particulate material;
- and
- (v) wherein the non-cytotoxic particulate material and cellular toxin are co-administered in two separate formulations.
Dependencies are inferred from the claim text.