Human endothelin receptor antibody and use thereof
AssigneeGmax Biopharm LLC
InventorsCheng Zhang, Hua Zhang, Xiaofeng Wang, Chenjiang Yao, Yan Jiang, Min Wang, Xinxin Shi, Hao Pan, Shuqian Jing
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Abstract
The present invention discloses an antibody specifically binding to a human endothelin receptor and uses thereof, where the antibody can inhibit the functions of the human endothelin receptor. The present invention includes the preparation, cloning, expression, and characterization of the antibody. The present invention can be used to effectively treat pulmonary arterial hypertension, a disease associated with pulmonary arterial hypertension, and a reproductive organ cancer in a human.
Claims10
An antibody that specifically binds to a human endothelin receptor, comprising:
- light chain CDR1 amino acid sequence:
- SEQ ID NO:
- 8;
- light chain CDR2 amino acid sequence:
- SEQ ID NO:
- 32;
- light chain CDR3 amino acid sequence:
- SEQ ID NO:
- 50;
- heavy chain CDR1 amino acid sequence:
- SEQ ID NO:
- 70;
- heavy chain CDR2 amino acid sequence:
- SEQ ID NO:
- 92;
- and
- heavy chain CDR3 amino acid sequence:
- SEQ ID NO:
- 116.
Dependencies are inferred from the claim text.