Nanoparticle complexes of albumin, paclitaxel, and anti-VEGF antibody for treatment of cancer
AssigneeMayo Foundation for Medical Education and Research
InventorsSvetomir N. Markovic, Wendy K. Nevala
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Abstract
This document provides materials related to treating cancer (e.g., skin cancer). For example, materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes (e.g., albumin-bound paclitaxel/anti-VEGF polypeptide antibody complexes) to treat cancer (e.g., skin cancer) are provided).
Claims15
An antibody-albumin nanoparticle complex comprising albumin, a bevacizumab antibody, and paclitaxel, wherein the nanoparticle complex has been pre-formed in vitro by mixing an aqueous albumin-paclitaxel nanoparticle with the antibody under conditions to form the nanoparticle complex, such that the nanoparticle complex has VEGF binding specificity, and wherein the complex has a diameter of between 0.1 μm and 1 μm.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and antibody-albumin nanoparticle complexes, said nanoparticle complexes comprising albumin, a bevacizumab antibody, and paclitaxel, wherein the nanoparticle complexes have been pre-formed in vitro by mixing aqueous albumin-paclitaxel nanoparticles with the antibody under conditions to form the nanoparticle complexes, such that the nanoparticle complexes have VEGF binding specificity, and wherein the average diameter of said complexes is between 0.1 μm and 1 μm.
A method of making an antibody-albumin nanoparticle complex, the method comprising mixing in vitro an aqueous albumin-paclitaxel nanoparticle with a bevacizumab antibody under conditions to form the nanoparticle complex, wherein the complex has a diameter of between 0.1 μm and 1 μm.
Dependencies are inferred from the claim text.