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US 10,376,573 B2Granted
Vaccines for serogroup X meningococcus
AssigneesGlaxosmithkline Biologicals SA, Institut Pasteur
InventorsMariagrazia Pizza, Peter Dull, Marzia Monica Giuliani, Muhamed-Kheir Taha, Eva Hong, Ala-Eddine Deghmane
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Abstract
A method for immunizing a subject against serogroup X meningococcus by administering a vaccine comprising one, two or all three of: (i) a meningococcal fHbp antigen; (ii) a meningococcal NHBA antigen; and/or (iii) a meningococcal NadA antigen. The vaccine may also include meningococcal outer membrane vesicles.
Claims13
A method for immunizing a subject in need thereof against serogroup X meningococcus by administering to the subject a composition comprising a meningococcal fHbp antigen and an aluminum salt adjuvant;
- wherein the meningococcal fHbp antigen comprises amino acid sequence SEQ ID NO:
- 7, wherein the composition either (a) is free from meningococcal outer membrane vesicles or (b) includes meningococcal outer membrane vesicles, and the fHbp antigen is present in the composition in soluble form, wherein the fHbp antigen is not conjugated to a meningococcal polysaccharide, and wherein the composition does not contain un-conjugated meningococcal polysaccharides.
Dependencies are inferred from the claim text.