Compositions and methods of enhancing immune responses to enteric pathogens
AssigneesBoard of Trustees of the University of Arkansas, The Texas A&M University System
InventorsLisa Bielke, Sherryll Layton, Billy Hargis, Neil R. Pumford, Olivia B. Faulkner, Luc Berghman, Daad Abi-Ghanem
Life of this patent
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Abstract
Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
Claims21
A vaccine vector comprising a first polynucleotide sequence encoding a PAL polypeptide consisting of a polypeptide selected from the group consisting of SEQ ID NO:
- 1, an amino acid sequence having 90% or more sequence identity to SEQ ID NO:
- 1 and an immunogenic fragment thereof at least six amino acids long and a second polynucleotide sequence encoding an HMGB1 polypeptide, wherein the PAL polypeptide and the HMGB1 polypeptide are expressed on the surface of the vaccine vector, and wherein the HMGB1 polypeptide comprises a polypeptide selected from the group consisting of at least one of SEQ ID NOs:
- 15-23.
A vaccine vector comprising a polynucleotide encoding a polypeptide selected from the group consisting of at least one of SEQ ID NO:
- 42, SEQ ID NO:
- 44, SEQ ID NO:
- 46, a polypeptide having 90% sequence identity to SEQ ID NO:
- 42, a polypeptide having 90% sequence identity to SEQ ID NO:
- 44, and a polypeptide having 90% sequence identity to SEQ ID NO:
- 46.
A vaccine vector comprising a first polynucleotide sequence encoding a PAL polypeptide consisting of a polypeptide selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 32, SEQ ID NO:
- 36, SEQ ID NO:
- 37 and combinations thereof, and a second polynucleotide encoding an HMGB1 polypeptide, wherein the PAL polypeptide and the HMGB1 polypeptide are expressed on the surface of the vaccine vector, and wherein the HMGB1 polypeptide comprises a polypeptide selected from the group consisting of at least one of SEQ ID NOs:
- 15-23.
Dependencies are inferred from the claim text.