Methods for systemically delivering polypeptides and microorganisms therefor
AssigneeWisconsin Alumni Research Foundation
InventorsJan Peter Van Pijkeren, Alan Attie, Mark Keller, Jee-Hwan Oh
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Abstract
Methods and microorganisms for systemically introducing a polypeptide in the bloodstream of a subject. The methods of the invention include administering into the gastrointestinal tract of a subject a bacterium configured to express and produce and release the polypeptide. The bacterium is administered in an amount effective to introduce the polypeptide in the bloodstream of the subject, preferably in a detectable amount. The microorganisms of the invention include lactic acid bacteria, such as Lactobacillus reuteri, that comprise a recombinant gene configured to express a polypeptide to be systemically introduced.
Claims11
A method of systemically introducing a polypeptide into a bloodstream of a subject, the method comprising administering into the gastrointestinal tract of the subject a bacterium that produces and releases the polypeptide, wherein the bacterium comprises a recombinant gene configured to express the polypeptide, wherein the bacterium is administered in an amount effective to introduce the polypeptide in the bloodstream of the subject in a detectable amount without the bacterium being introduced in the bloodstream of the subject in a detectable amount, wherein the bacterium is Lactobacillus reuteri.
Dependencies are inferred from the claim text.