Aqueous solution formulations of vancomycin

A clear and injectable solution composition, said solution composition comprising:

• (a) a glycopeptide selected from the group consisting of vancomycin having an empirical formula of C66H75Cl2N9O24, norvancomycin or salts thereof, at a concentration of about 0.1% w/v to about 12% w/v;
• (b) tryptophan having an empirical formula of C11H12N2O2 selected from the group consisting of the L-form, the D-form, a mixture of the L- and D-forms or salts thereof, at a concentration between about 0.1% w/v to 2.5% w/v, wherein tryptophan inhibits formation of crystalline degradation product-1 (CDP-1);
• (c) water, wherein the pH of the solution composition is between about 3 to about 6;
• and CDP-1 is no more than 4% based on high performance liquid chromatography (HPLC) peak area after storage at 2-8° C. for 20 months.