Formulations of vancomycin
AssigneeScidose LLC
InventorsNagesh R. Palepu, Philip Christopher Buxton
Life of this patent
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Abstract
Liquid vancomycin containing compositions having extended shelf life are disclosed. The compositions contain vancomycin or a pharmaceutically acceptable salt thereof, a polyol such as glycerol, and lactic acid or a lactate. The compositions are ready to use and easily transferred into larger parenteral solutions prior to administration to patients in need thereof.
Claims16
A liquid vancomycin-containing composition, consisting of from about 50 mg/mL to about 250 mg/mL of vancomycin or a pharmaceutically acceptable salt thereof, glycerol, a member of the group consisting of lactic acid, lactate or mixtures thereof, a base and a pharmaceutically acceptable fluid containing water, said vancomycin-containing composition having a pH of from about 5.5 to about 6.5 and being suitable for parenteral administration, wherein the amount of glycerol is from about 15 to about 30% (v/v).
A liquid vancomycin-containing composition, consisting of about 75 mg/mL to about 220 mg/mL vancomycin or a pharmaceutically acceptable salt thereof;
- about 15% (v/v) to about 30% (v/v) glycerol, a stabilizing amount of a member of the group consisting of lactic acid, lactate or mixtures thereof, a base and a pharmaceutically acceptable fluid containing water, wherein the liquid vancomycin containing composition has a pH of from about 5.5 to about 6.5 and is suitable for intravenous administration.
A liquid vancomycin-containing composition, consisting of about 200 mg/mL of vancomycin or a pharmaceutically acceptable salt thereof, about 25 to 30% (v/v) glycerol, a member of the group consisting of lactic acid, lactate or mixtures thereof, a base and water, the liquid vancomycin composition having a pH of from about 4.5 to about 7.5.
Dependencies are inferred from the claim text.