Peptide fragments for inducing synthesis of extracellular matrix proteins
AssigneeHelix Biomedix, Inc.
InventorsScott M. Harris, Timothy J. Falla, Lijuan Zhang
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Abstract
Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
Claims19
A skincare composition comprising a tetrapeptide consisting of SEQ ID NO:1 or SEQ ID NO:14, and a dermatologically acceptable carrier.
A method for promoting wound healing of skin damaged by normal aging, disease, injury, trauma, or by surgery or other medical procedures, comprising administering to a human in need thereof a therapeutically effective amount of a composition comprising a tetrapeptide and a pharmaceutically acceptable carrier, wherein the tetrapeptide consists of SEQ ID NO:1 or SEQ ID NO:14 and has an acid or amidated carboxy-terminus.
Dependencies are inferred from the claim text.