Methods and compositions for modulating transport of a drug
OwnerJeffrey D. Laskin, Ron Udasin +1inventors
InventorsJeffrey D. Laskin, Ron Udasin, Lauren Aleksunes
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Abstract
Methods and pharmaceutical compositions for inhibiting or decreasing transport of a drug by a transporter of multidrug resistance-associated protein comprising a compound of Formula (IV) wherein R1 and R2 are small peptides or modified peptides, are provided. The methods and compositions are useful in enhancing efficacy of drugs such as anti-inflammatory agents, neurological agents, thyroid agents, ocular agents, cancer chemotherapeutics, antibiotics, antimicrobials, antivirals and protease inhibitors to treat human immunodeficiency virus.
Claims13
A method for inhibiting or decreasing transport of a drug by a transporter of multidrug resistance-associated protein in a cell, said method comprising administering to the cell a compound of Formula (IV)
- wherein R1 and R2 are small peptides or modified peptides;
- and wherein the cell is a microbe.
A method for inhibiting or decreasing transport of a drug by a transporter of multidrug resistance-associated protein in a cell, said method comprising administering to the cell a drug that is a substrate for the transporter of multidrug resistance-associated protein and a compound of Formula (IV)
- wherein R1 and R2 are small peptides or modified peptides.
A pharmaceutical composition for inhibiting or decreasing transport of a drug by a transporter of multidrug resistance-associated protein in a cell, said composition comprising a compound of Formula (IV)
- wherein R1 and R2 are small peptides or modified peptides, a drug that is a substrate for the transporter of multidrug resistance-associated protein, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.