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US 10,376,555 B2Granted
Identification of cyclic peptide agonists of galanin receptor 2 and 3 guided by spexin solution structure
AssigneeHong Kong Baptist University
InventorsZhaoxiang Bian, Tao Huang, Chengyuan Lin
Life of this patent
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Abstract
Cyclic peptide agonists toward human galanin receptor 2 (GalR2) and galanin receptor 3 (GalR3) based on hidden conformation of spexin solution structure for GalR2 and GalR3-related and spexin-deficient disorders are designed and synthesized. LH101, LH102, and LH101 (Ac) are potent spexin analogs with prolonged action, which can be used in the treatment of GalR2 and GalR3-related diseases and spexin-deficient disorders, such as obesity.
Claims19
A peptide comprising a sequence having at least 92.8% homology with SEQ ID NO:
- 23 or SEQ ID NO:
- 24;
- or having at least 93.7% homology with SEQ ID NO:
- 25 or a therapeutically effective salt thereof, wherein R1 is hydrogen, alkyl, or acyl with the proviso that SEQ ID NO:
- 23 must contain cysteine at position one and position thirteen of SEQ ID NO:
- 23;
- SEQ ID NO:
- 24 must contain cysteine at position four and position thirteen of SEQ ID NO:
- 24;
- and SEQ ID NO:
- 25 must contain cysteines at position one and position thirteen of SEQ ID NO:
- 25.
9 more elements
A peptide consisting of SEQ ID NO:
- 23;
- SEQ ID NO:
- 24;
- or SEQ ID NO:
- 25 or a therapeutically effective salt thereof, wherein R1 is hydrogen, alkyl, or acyl.
2 more elements
Dependencies are inferred from the claim text.