US 10,376,553 B2 · Pharmaceutical composition for preventing and treating chronic obstructive lung disease containing, as active ingredient, Magnoliae flos extract, fraction, or active fraction thereof

Abstract

A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-α and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.

Claims11

Dependent claims

A method for treating chronic obstructive pulmonary disease in a subject in need thereof, which comprises administering a pharmaceutically effective amount of (i) an extract of Magnoliae flo, (ii) an active fraction obtained by fractionation of the extract of Magnoliae flos with an organic solvent, or (iii) a combination of (i) and (ii) to the subject.

Dependencies are inferred from the claim text.

Facts

Application

15/573,207Filed 13 May 2016

Priority

KR 10-2015-006662113 May 2015

Published

US 2018/0353561 A113 Dec 2018

Granted

13 Aug 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 36/575
Magnoliaceae: magnolia
A61K 31/34
Having oxygen as the only ring hetero atom, e.g. fungichromin: having five-membered rings with one oxygen as the only ring hetero atom, e.g.…
A61K 31/357
Having oxygen as the only ring hetero atom, e.g. fungichromin: having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
A61K 31/36
Having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel: compounds containing methylenedioxyphenyl groups, e.g. sesamin

Pharmaceutical composition for preventing and treating chronic obstructive lung disease containing, as active ingredient, Magnoliae flos extract, fraction, or active fraction thereof

Life of this patent

Pharmaceutical composition for preventing and treating chronic obstructive lung disease containing, as active ingredient, Magnoliae flos extract, fraction, or active fraction thereof

Life of this patent

Abstract

Claims11