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US 10,376,545 B2Granted
Methods for producing hormone secreting cells in a subject
AssigneeViaCyte, Inc.
InventorsAlan D. Agulnick, Kevin Allen D'Amour
Life of this patent
Estimating the term…
Abstract
A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
Claims18
A method for producing hormone secreting cells, said method comprising:
- maturing transplanted endocrine cells in vivo in a subject wherein the endocrine cells co-express INS+ and NKX6.1+, thereby producing hormone secreting cells.
A method for producing hormone secreting cells, said method comprising:
- maturing transplanted human cells in vivo, wherein the transplanted human cells comprise unipotent human immature beta cell suspension aggregates and wherein at least 10% of cells in the beta cell suspension aggregates are human immature beta cells that co-express INS and NKX6.1,
- thereby producing hormone secreting cells.
Dependencies are inferred from the claim text.