Therapy for malignant disease
AssigneeUniversity of Rochester
InventorsRichard G. Moore, Rakesh K. Singh, Naohiro Yano
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Abstract
Provided herein, inter alia, are methods and compositions directed to suppressing tumor cell growth in a subject as well as methods for sensitizing a proliferating cell for treatment with a cytotoxic agent via inhibiting expression of HE4 and one or more immune checkpoint inhibitors (ICIs). Also provided herein are methods for determining whether a subject who has been diagnosed with cancer would benefit from immunotherapy as well as methods for determining whether a subject with cancer is responding to immunotherapy via assessment of levels of HE4 gene and/or protein expression.
Claims11
A method of suppressing tumor cell proliferation in a subject comprising:
- concurrently or sequentially inhibiting
- (a) the activity or level of human epididymal secretory protein E4 (HE4) in said tumor cell;
- and
- (b) the activity or level of one or more immune checkpoint inhibitors (ICIs) in the cell, thereby suppressing tumor cell proliferation in said subject,
- wherein the HE4 level in said tumor cell is >400 pM,
- wherein said level of HE4 in said tumor cell is inhibited by administering an effective amount of an HE4 inhibitor to said tumor cell,
- wherein the ICI comprises PD-L1,
- wherein the level of said one or more ICIs in said tumor cell is inhibited by administering an effective amount of an ICI inhibitor to said tumor cell, and
- wherein said tumor cell is a Müllerian cancer cell.
Dependencies are inferred from the claim text.