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US 10,376,529 B2Granted
Combination of pentacyclic triterpenes and hydroxytyrosol and derivatives thereof
AssigneeNatac Biotech, S.L.
InventorsJosé Carlos Quintela Fernández, Esther De La Fuente García, Marco Pugliese, Pilar Mancera Aroca, Javier Bustos Santafé, Juan Francisco Espinosa Parrilla, Noemí Virgili Treserres, Blanca Wappenhans Battestini
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Abstract
The present invention is related to a product comprising a pentacyclic triterpene of formula (I) and a hydroxytyrosol or derivatives thereof of formula (II), pharmaceutical compositions thereof and their uses as antioxidants, anti-inflammatories and neuron protectors.
Claims5
A composition comprising:
- a) 1, 2, 3, 4, or 5 compounds selected from the group consisting of oleanolic acid, maslinic acid, ursolic acid, erythtodiol and uvaol;
- or pharmaceutically acceptable salts thereof;
- and
- b) 1, 2 or 3 compounds selected from the group consisting of hydroxytyrosol, verbascoside, and 3,4-dihydroxyphenylglycol;
- or pharmaceutically acceptable salts thereof;
- wherein the weight of the compounds of (a) with respect to the weight of the compounds of (b) is in the range from 10:1 to 1:1;
- with the provisos that:
- the product comprises 3,4-dihydroxyphenylglycol,
- when the product comprises oleanolic acid and hydroxytyrosol, then the weight of oleanolic acid is at least 3 times the weight of hydroxytyrosol;
- and
- when the product comprises hydroxytyrosol, maslinic acid and oleanolic acid in a weight ratio maslinic acid/oleanolic acid greater than 1, then the weight of maslinic acid is at least 10 times the weight of hydroxytyrosol.
8 more elements
Dependencies are inferred from the claim text.