Methods for the treatment of autoimmune diseases
AssigneeUCL Business PLC
InventorsShawn Ellis, Clare Notley, Michael Ehrenstein
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Abstract
The present invention provides a method for inducing CD8+FOXP3+ regulatory T cells in a subject which comprises administering to the subject: (i) a first agent which inhibits p38 phosphorylation; and (ii) a second agent which stimulates T-cell receptor (TCR) signalling. The method may be used to treat and/or prevent an autoimmune and/or inflammatory disease in a subject. The invention also provides compositions and kits for use in such methods.
Claims11
A method for inducing CD8+FOXP3+ regulatory T cells in a subject which comprises administering to the subject:
- (i) a first agent which inhibits p38 phosphorylation;
- and
- (ii) a second agent which is an anti-CD3 antibody;
- wherein the subject is a non-responder to anti-CD3 therapy alone, showing no significant increase in FOXP3 expression on CD8+ T cells following anti-CD3 stimulation, and wherein the first agent is administered to the subject followed by the second agent or the two agents are administered simultaneously.
A method of treating an autoimmune and/or inflammatory condition in a subject, comprising administering to the subject a first agent which inhibits p38 phosphorylation in CD8+ T cells and a second agent which is an anti-CD3 antibody, wherein the first agent enhances the efficacy of an anti-CD3 antibody, and wherein the subject is a non-responder to anti-CD3 therapy alone, showing no significant increase in FOXP3 expression on CD8+ T cells following anti-CD3 stimulation, and wherein the first agent is administered to the subject followed by the second agent or the two agents are administered simultaneously, and wherein the autoimmune and/or inflammatory condition is selected from:
- pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, atopic dermatitis, vitiligo, Sjogren's syndrome, glomerulonephritis, IgA nephropathy, atopic dermatitis and anti-phospholipid syndrome.
Dependencies are inferred from the claim text.