Back to results
US 10,376,515 B2Granted
Analogs of adenosine monophosphate (AMP) as inhibitors of ubiquitin-like modifier-activating enzyme ATG7
AssigneeNorthwestern University
InventorsAlexander V. Statsyuk, Heeseon An
Life of this patent
Estimating the term…
Abstract
Disclosed are analogs of adenosine monophosphate (AMP) as inhibitors of ubiquitin-like modifier-activing enzyme ATG7. The AMP analogs may be formulated as pharmaceutical compositions for treating diseases or disorders that depend on ATG7 activity and/or autophagy such as cell proliferative diseases and disorders.
Claims14
A compound of Formula Ib′:
- wherein:
- X is CH2, NH, O, or S;
- Y is an electrophile;
- or Y and X together form a 3-membered, 4-membered, 5-membered, 6-membered, or 7-membered carbocycle or heterocycle which optionally is unsaturated at one or more bonds and which optionally includes a carbonyl substituent.
1 more element
Dependencies are inferred from the claim text.