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US 10,376,495 B2Granted
Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
AssigneesUniversity of South Florida, The United States Government as Represented by the Department of Veterans, H. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorsJuan Sanchez-Ramos, Vasyl Sava, Shijie Song, Said Sebti
Life of this patent
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Abstract
Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.
Claims12
A method of treating a condition in a subject, the method comprising administering a compound to the subject,
- wherein the compound is
- wherein the condition is selected from the group consisting of neurodegenerative disease, stroke, traumatic brain injury (TBI), impaired motor function, and impaired cognitive function.
Dependencies are inferred from the claim text.